Humphrey won the party's nomination at the Convention on the first ballot, amid riots in Chicago.
He selected little-known Senator Edmund Muskie of Maine as his running mate.
During the general election, Humphrey faced former Vice President Richard Nixon of New York, the Republican Party nominee.
Nixon led in most polls throughout the campaign, and successfully criticized Humphrey's role in Vietnam, connecting him to the unpopular president and the general disorder in the nation.
Johnson had been stalled by the anti-Vietnam War candidacy of Senator Eugene Mc Carthy of Minnesota, who along with Senator Robert F.
Kennedy of New York, became the main opponents for Humphrey.
The contest between the men featured a battle for control of the Democratic Party, and cast Humphrey's "old politics", against the "new politics" of Mc Carthy and Kennedy.
But Humphrey was able to convince Johnson to speak to the influential National Farmers Union in Minneapolis, ahead of the Wisconsin Primary.
which led many Americans to believe that the North Vietnamese were stronger than had been reported, and that the war was not nearing an end.
From this point, most Americans either believed that the war should be escalated to completely destroy the enemy or that all American troops should be withdrawn from Vietnam to prevent the use of any more resources for the "hopeless task".
He served two, two-year terms, and gained a reputation as an anti-Communist and ardent supporter of the Civil Rights Movement.
He gave a rousing speech at the 1948 Democratic National Convention arguing for the adoption of a pro-Civil Rights plank, exclaiming "The time has arrived in America for the Democratic Party to get out of the shadow of states' rights and to walk forthrightly into the bright sunshine of human rights." That same year, he was elected to the United States Senate, where he worked closely with Senate Majority Leader Lyndon Johnson.
As Vice President, Humphrey oversaw turbulent times in America, including race riots and growing frustration and anger over the large number of casualties in the Vietnam War.